CHAN SIOK YEE (DR.)'s Journal /
The improved dissolution performance of a post processing treated spray-dried crystalline solid dispersion of poorly soluble drugs. | 6. Publication and Oral presentation by Chan Siok Yee (Sam)

Solution-mediated transformation has been cited as one of the main problems that deteriorate dissolution performances of solid dispersion (SD). This is mainly attributed by the recrystallization tendency of poorly soluble drug. Eventually, it will lead to extensive agglomeration which is a key process in reducing the dissolution performance of SD and offsets the true benefit of SD system. Here, a post-processing treatment is suggested in order to reduce the recrystallization tendency and hence bring forth the dissolution advantage of SD system.